CHOLINE AND INOSITOL 300mg/300mg

• Choline & Inositol = Perfect combo for your brain
• Food supplement made from Choline Bitartrate and Inositol
• 300mg of each substance in a single capsule!
• Vegetable capsules made from cellulose, Suitable for vegans!

What is Choline and Inositol?

Choline and Inositol by HSNessentials is a food supplement made from choline bitartrate and myo-inositol; the product has been encapsulated with a vegetable glazing agent obtained through cellulose polymerization. Therefore, it is suitable both for vegans and vegetarians.

Choline and Inositol is a product made up by two substances with important functions in the organism of human beings. In fact, they are in charge of catalyzing (or regulating) metabolic reactions.

Choline and Inositol by HSNessentials contains 300mg of choline bitartrate and 300mg of myo-inositol per capsule!

Why take Choline and Inositol?

Choline is a nutrient that is functionally similar to a vitamin from the B complex; that is why it is sometimes classified as a 'vitamin' even though it is not one. The Choline from our organism performs several functions; among others, a cognitive function.

The choline that crosses the blood-brain barrier (layer of blood that surrounds our brain) binds to a molecule called Acetyl-CoA with the help of an enzyme called Acetyltransferase. Together, they make Acetylcholine in the neurons (Boron & Boulpaep, 2016); the neuron that produces acetylcholine is a presynaptic neuron (or emitter) of the nerve impulses; this is due to the fact that acetylcholine is the main brain neurotransmitter in charge of transmitting information between neurons. Moreover, it is the trigger that starts the muscle contraction process in the skeletal muscle. Therefore, having choline in the organism “is necessary for a good nerve impulse through the central nervous system” (DrugBank, 2019a).

When acetylcholine reaches the postsynaptic neuron (or receptor) of the nerve impulse, it triggers a process that involves the breakdown of phospholipids, which are the main component from the neuron membranes. This results in a complex reaction sequence that allows the efficient transmission of information between neurons. In fact, it is known that alterations in the acetylcholine metabolism can negatively affect the coding processes of the memory, resulting in the onset of neurodegenerative diseases in the long-term.

Phosphatidylinositol 4,5-bisphosphate is the phospholipid that breaks down when acetylcholine reaches the receptor neuron. It is a metabolite of inositol, therefore, the “ability of the cell to maintain a proper supply of myo-inositol is crucial for the resynthesis of phosphatidylinositol and to preserve the efficacy of the impulse” (Harvey et al., 2002).

This process does not only occur in specific brain neurons, rather, it also happens in other locations where there is a nerve impulse, even modulating our immune system, illustrated by Lappin and Nile (2012).

“The inositol we take through the diet adheres to the nervous cell membranes as inositol-phospholipid where it works as a metabolic key” (Harvey et al., 2002)

Moreover, acetylcholine does not only produces this signalling regulated by phosphatidylinositol bisphosphate. There are several subtypes of metabotropic receptors (adrenergic, serotonergic and glutamatergic) that hydrolyze phosphatidylinositol bisphosphate. That is why it is currently being studied if myo-inositol could be a potential treatment against obsessive-compulsive disorder, depression, panic attacks and anxiety; from the moment we found out that “the myo-inositol concentrations in the brain are connected to mood swings” (Chhetri, 2019).

The combination of choline and inositol by HSNessentials allows us to get a supply of the precursors of the metabolic processes we have previously mentioned, whose acetylated and phosphorylated metabolites help to maintain a proper neuronal balance.

When is the best time to take Choline and Inositol?

You will just have to take one capsule of Choline and Inositol by HSNessentials a day with a meal.

Its compounds seem to work in the long-term, and there are no studies that state that we can benefit from its intake at a specific time of the day.

How can we combine Choline and Inositol?

• Evovits
• Acetyl-L-Carnitine
• Fish Oil

Bibliography

• Boron, W., Boulpaep, E. (Eds.) (2009) Medical physiology: a cellular and molecular approach Philadelphia, PA: Saunders/Elsevier.
• Chhetri, D. R. (2019). Myo-Inositol and Its Derivatives: Their Emerging Role in the Treatment of Human Diseases. Frontiers in Pharmacology, Vol. 10.
• DrugBank (2019a). Choline - DrugBank.
• Harvey, B. H., Brink, C. B., Seedat, S., & Stein, D. J. (2002). Defining the neuromolecular action of myo-inositol: application to obsessive-compulsive disorder. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 26(1), 21–32.
• Hasselmo, M. (2007). The Role of Acetylcholine in Learning and Memory. Current Opinion in Neurobiology, 16, 710–715.
• Zoheir, N., Lappin, D., & Nile, C. (2012). Acetylcholine and the alpha 7 nicotinic receptor: A potential therapeutic target for the treatment of periodontal disease? Inflammation Research?: Official Journal of the European Histamine Research Society ... [et Al.], 61, 915–926.