Evobrain In Depth: Review to Discover its Key Points

Alfredo Valdés 15 min. of reading Concentration and Memory Leave a comment

Evobrain is a dietary supplement designed to enhance cognitive abilities. Therefore, it can be used, among others, by those who are studying in high school, university, competitive exams, psychotechnical tests…

Index

1 What is Evobrain
2 What Evobrain is Used For
3 How Evobrain Works
4 Real Role of Choline
5 Why Do We Use Blueberry Extract?
6 The Role of Bacopa monnieri in Evobrain
7 Rhodiola rosea to Crown Evobrain
8 Does Evobrain Have Side Effects?
9 We Have Renewed Evobrain

What is Evobrain

Evobrain is a dietary supplement crafted by specialists in the use of nootropics, as an exclusive formula for HSN, and is intended for the improvement of intellectual performance during periods of stress and high cognitive demands.

Evobrain is designed for you!

What Evobrain is Used For

Whether you’re preparing for a competitive exam, studying for a university exam, preparing a project for work, or because you’re interested in enhancing focus in a chess, poker, or other sports competition that requires high concentration…

Nootropic

Evobrain contains nootropic substances, meaning they support cognitive performance through multiple pathways.

In the case of Evobrain:

Through the increase of the amount of “chemical messengers” in our brain.
Through the structural development of neurons which allows them to receive more messengers.

Evobrain is a stimulant-free nootropic formula.

Mood Improvement

Evobrain has been formulated with a matrix of compounds that have different therapeutic action targets to put you in neurohacker mode.

Without stimulants that could alter your mood or cause the classic discomfort of headaches, energy slumps, or nervousness.

Adaptogen

Evobrain also contains an adaptogenic compound, which is used to maintain mood, and the predisposition to study; can prevent episodes of acute anxiety and sadness; and helps your body adapt to stressful stimuli to which study hours subject it.

Evobrain also helps by maintaining emotional balance during concentration sessions.

How Evobrain Works

Cholinergy

Evobrain contains the best source of choline: citicoline or CDP-Choline, a novel choline salt that has been positioned as the most bioavailable for its neurological properties.

Choline is a pseudo-essential nutrient that we are capable of producing, but in insufficient amounts for all the functions it performs in the body.

Among them, the cognitive role of choline is well known among neurologists who deal with episodic memory loss or cognitive impairment.

Why?
Because acetylated choline is acetylcholine; one of our major brain neurotransmitters.

Acetylcholine

Acetylcholine is a neurotransmitter, that is, a chemical substance that our neurons use to transmit messages.

Imagine that acetylcholine is a messenger pigeon: a neuron (sender) ties a paper with a message to the legs of the acetylcholine (messenger pigeon), so it reaches another neuron (receiver) thus continuing the communication chain neuron-neuron-neuron-neuron throughout the entire neural network that forms our nervous system.

If you want to learn more about neurotransmitters, click .

This is important because acetylcholine, in its process of transmitting information between neurons, is responsible for encoding new memories and consolidating data, regulating working memory, the recognition of objects and concepts, and mental agility (Hasselmo et al., 2006)

How many of these factors sound like they will make your study more efficient? Many, right?

Real Role of Choline

The function of choline on cognitive performance is not only limited to theory but to the paper as well!

Do you have trouble concentrating and maintaining focus during study? You may suffer from a choline deficit.

We have an extensive body of scientific literature that has associated nutritional deficiency of choline with cognitive impairments, and increased intake with higher mental performance.

Low levels of choline in the blood are associated with poor cognitive performance at various levels (Nurk et al., 2012).

Higher intakes of choline are associated with better mental performance in a dose-dependent manner (Blusztajn, Slack, and Mellott, 2017).

Scores from two word recall tests (immediate repetition – left / delayed repetition – right) based on the amount of choline ingested, X-axis.

The use of choline in the form of a dietary supplement before a task has proven effective in improving performance in a task with high demands for concentration, similar to a psychotechnical test (Naber et al., 2015).

Effects of choline supplementation on a performance test of attentional style shooter. Hit distance: distance to the target, RT: reaction impulses; Misses: errors.

And citicoline is the best current form available to provide this nutrient for its cognitive effects. A must in your daily supplementation as a student.

Why Do We Use Blueberry Extract?

The blueberry (Vaccinium uliginosum) is a fruit with high antioxidant power ORAC, which means it is capable of facing one of the main problems associated with the deterioration of cognitive performance, which is accentuated in adult students: men and women who return to their studies in their 30s, 40s, or 50s; or in university students exposed to high levels of oxidative stress, such as high-altitude athletes, for example.

The main mechanism through which blueberry extract can help intellectual performance is through neuroplasticity, defined as the ability of the brain’s neural network to adapt through growth and reorganization.

Neural plasticity is a key feature for learning in children, which is why they are so prone to learning things while adults are more resistant to new learning.

The consumption of blueberries promotes the neuroplasticity of brain regions such as the hippocampus and the central cortex through the stimulation of trophic factors including the famous BDNF (brain-derived neurotrophic factor) or IGF-1 (insulin-like growth factor type 1) (Shukitt-Hale et al., 2008).

The Role of Bacopa monnieri in Evobrain

Bacopa monnieri is a plant widely used in Ayurvedic medicine for the treatment of confusion and states of cognitive and emotional imbalance.

These effects have continued to our times, currently being studied as a possible nutraceutical with beneficial effects against neurological disorders and memory loss caused by neurodegenerative diseases such as Alzheimer’s (Chaudhari et al., 2017).

Morphology of the Bacopa monnieri plant and structure of a bacoside.

Bacopa monnieri possesses unique active principles called bacosides; these seem to be responsible for Bacopa’s actions at the neurological level.

Bacosides act in synergy with CDP-Choline, inhibiting the degradation of acetylcholine once it is released by the sending neuron, allowing not only more acetylcholine to be released but also less to be lost in the process.

Effects of Bacopa monnieri on increasing memory through the increase in availability of acetylcholine by inhibition of the enzyme responsible for its degradation (acetylcholinesterase).

Bacopa monnieri complements the two cholinergic targets of action that any “smart drug” should have;

It is currently perhaps the herbal extract that has demonstrated the most potency in humans on improving concentration, memory, selective attention, and the loss of cognitive performance over time in front of a demanding task (Calabrese et al., 2008; Kongkeaw et al., 2014; Kean et al., 2017).

But not only that:

It has also proven to be effective in reducing anxiety in front of a mentally demanding task (Calabrese et al., 2008); and
The inhibition of pathways that produce inflammation in the brain and that can alter our cognitive performance (Nemetchek et al., 2018).

The administration of Bacopa monnieri decreased the wear and tear of neurons, allowing them to “grow” and develop more extremities (dendrites), increasing the amount of acetylcholine they can produce and capture; and improving cognitive performance by these effects (Aguiar and Borowski, 2013). This is a mechanism of action that presents great synergy with the neurotrophic activity of blueberry extract.

Representation of dendritic development of amygdaloid neurons in basolateral localization.

Why Bacopa from Evobrain?

Remember when your mother told you to drink the juice because the vitamins were going away?

She might have been exaggerating a bit, but the truth is that it depends how you treat a product, it will preserve its active principles to a greater or lesser extent (in orange juice, vitamin C).

Now imagine that you, who consume Bacopa monnieri for the neurological effects of its bacosides were consuming a plant that had been grown in poor conditions, that had dried out, that had been damaged during its harvest, and that had been extracted using very intense organic solvents…

The content of bacosides would be very low because the plant has been very mistreated, and the final product, no matter how much you take, will not serve to achieve the desired effects.

Featured display of the content of bacosides in the leaf extract of Bacopa monnieri used in the latest version of Evobrain.

In Evobrain we have used a Bacopa monnieri extract with a standardized content of bacosides at 30%, thus ensuring the concentration of the active principle you will consume so you can be assured that it will produce the effects you pursue through its consumption.

Rhodiola rosea to Crown Evobrain

We know that studying is hard, dedicating many hours to a task that demands a large amount of cognitive resources becomes uphill and sometimes anxiety, stress, and difficulty in dealing with the situation appear.

Rhodiola rosea is a plant whose roots have been used in traditional medicine to treat anxiety and relax people without leaving them “dazed,” as if it were a stress support.

That is why Rhodiola rosea has been studied as a nutraceutical adaptogen.

An adaptogen is a substance that helps us maintain a correct balance in the body, at a physical and mental level, in front of a situation that alters us and makes us lose our homeostasis, keep reading.

Rhodiola rosea and Anxiety

Rhodiola rosea and its active principles (salidrosides and rosavins) have been studied for their immunomodulatory, anti-aging, neuroprotective functions and, of course, enhancers of resistance against stress.

Multiple mechanisms have been found through which Rhodiola rosea can improve all these organic systems; many of them are proposed in the following image, but they will not be explained due to the great complexity of the field.

Mechanisms of action demonstrated through which the extract of Rhodiola rosea can exert an ergogenic effect.

However, it is important to keep in mind that Evobrain contains an effective dose of Rhodiola rosea, effective for it to exert the positive neurological functions on the body.

Rhodiola rosea has demonstrated a very potent effect in the treatment of behavioral anxiety, that is, that anxiety that appears due to an acute episode that subjects us to a high degree of stress, such as studying for an exam (Bangratz et al., 2018).

One of the most interesting features of Rhodiola rosea is that unlike other adaptogens such as ashwagandha, maca, or ginseng; this has been very studied in its effects on cognitive performance.

It has been seen how it is very effective in improving performance (increasing the speed of resolution and the number of mistakes made) in demanding cognitive situations involving high degrees of stress (Ma et al., 2018).

Does Evobrain Have Side Effects?

Evobrain is a dietary supplement developed following the highest quality standards of the supplementation industry, accredited by independent certifying companies that verify that our product developments and manufacturing procedures are optimal. Read more here.
Evobrain has no adverse or secondary effects, at the established daily dose of 4 vegetable capsules; it provides effective and safe amounts according to the reports of the most rigorous and internationally recognized expert entities, guaranteed.
It is compatible with any other dietary supplement that does not contain the compounds already in its composition, including caffeine and other neurostimulants, which can be used simultaneously with the use of Evobrain.

You can (and should) use Evobrain daily, continuously for weeks. You do not have to stop using it after a while, nor do you need to take breaks.

Evobrain continues to be safe and effective in the long term without the need to cycle its use.

If you are undergoing pharmacological treatment for any medical condition, especially in the case of antidepressants, hypnotics, or cognitive stimulants; we recommend that you consult your doctor before incorporating Evobrain into your daily supplementation.

We Have Renewed Evobrain

At HSN, the desire to grow and continue improving overpowers us; since our beginnings more than a decade ago we have not stopped doing so.

We have improved Evobrain at the pace we ourselves have been growing, always optimizing the sources of the product, the raw materials used for its manufacture, but maintaining the same essence of the first Evobrain manufactured.

Evolution of Evobrain over 7 years of commercialization.

In our latest update, we have included blueberry extract for its properties linked to the support of neuroplasticity, and we have improved the way of using Evobrain, reducing the number of capsules needed to reach the recommended daily dose, without reducing it.

We have changed the format of the product, since previously, due to the need to use a greater number of capsules per day the available formats of Evobrain were: 90 and 180 veg caps; less practical options than our more traditional formats of 30 and 120 veg caps.
With the improvement of the composition of Evobrain and the optimization of the mode of use of the formula, we have renewed the format of the dietary supplement, and now you have Evobrain available in formats: 30 and 120 vegetable capsules.
In addition, since two previous versions of improving Evobrain we use a capsule size that is easier to swallow, having reduced the size from 000 to 00.

Encapsulation size scale.

Thanks to the latest improvement in the composition of Evobrain, now only 2 capsules need to be consumed twice a day to obtain all the effects of Evobrain, instead of the 6 capsules required in the previous version.

More potency and more focus with our renewed Evobrain! Maintaining all our original essence.

Bibliographic Sources

Aguiar, S., & Borowski, T. (2013). Neuropharmacological review of the nootropic herb Bacopa monnieri. Rejuvenation Research, 16(4), 313–326.
Bangratz, M., Abdellah, S. A., Berlin, A., Blondeau, C., Guilbot, A., Dubourdeaux, M., & Lemoine, P. (2018). A preliminary assessment of a combination of rhodiola and saffron in the management of mild–moderate depression. Neuropsychiatric Disease and Treatment, 14, 1821–1829.
Blusztajn, J. K., Slack, B. E., & Mellott, T. J. (2017). Neuroprotective actions of dietary choline. Nutrients, 9(8).
Calabrese, C., Gregory, W. L., Leo, M., Kraemer, D., Bone, K., & Oken, B. (2008). Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: A randomized, double-blind, placebo-controlled trial. Journal of Alternative and Complementary Medicine, 14(6), 707–713.
Chaudhari, K. S., Tiwari, N. R., Tiwari, R. R., & Sharma, R. S. (2017). Neurocognitive effect of nootropic drug Brahmi (Bacopa monnieri) in Alzheimer’s disease. Annals of Neurosciences, 24(2), 111–122.
Kongkeaw, C., Dilokthornsakul, P., Thanarangsarit, P., Limpeanchob, N., & Norman Scholfield, C. (2014). Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract. Journal of Ethnopharmacology, 151(1), 528–535.
Ma, G., Zheng, Q., Xu, M., Zhou, X., Lu, L., Li, Z., & Zheng, G.-Q. (2018). Rhodiola rosea L. Improves Learning and Memory Function: Preclinical Evidence and Possible Mechanisms. Frontiers in Pharmacology, 9, 1415.
Naber, M., Hommel, B., & Colzato, L. S. (2015). Improved human visuomotor performance and pupil constriction after choline supplementation in a placebo-controlled double-blind study. Scientific Reports, 5(1), 13188.
Nemetchek, M. D., Stierle, A. A., Stierle, D. B., & Lurie, D. I. (2017). The Ayurvedic plant Bacopa monnieri inhibits inflammatory pathways in the brain. Journal of Ethnopharmacology, 197, 92–100.
Nurk, E., Refsum, H., Bjelland, I., Drevon, C. A., Tell, G. S., Ueland, P. M., … Smith, D. A. (2013). Plasma free choline, betaine and cognitive performance: The Hordaland Health Study. British Journal of Nutrition, 109(3), 511–519.
Peth-Nui, T., Wattanathorn, J., Muchimapura, S., Tong-Un, T., Piyavhatkul, N., Rangseekajee, P., … Vittaya-Areekul, S. (2012). Effects of 12-week bacopa monnieri consumption on attention, cognitive processing, working memory, and functions of both cholinergic and monoaminergic systems in healthy elderly volunteers. Evidence-Based Complementary and Alternative Medicine, 2012, 606424.
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Shukitt-Hale, B., Lau, F. C., Carey, A. N., Galli, R. L., Spangler, E. L., Ingram, D. K., & Joseph, J. A. (2008). Blueberry polyphenols attenuate kainic acid-induced decrements in cognition and alter inflammatory gene expression in rat hippocampus. Nutritional neuroscience, 11(4), 172–182.
Traini, E., Bramanti, V., & Amenta, F. (2013). Choline Alphoscerate (Alpha-Glyceryl-Phosphoryl-Choline) An Old Choline- containing Phospholipid with a Still Interesting Profile As Cognition Enhancing Agent. Current Alzheimer Research, 10(10), 1070–1079.
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