•  Gzymes (Enzyme blend) is an exclusive HSN formula - You won’t find it in other brands.
•  Specific enzyme mix: Papain, prolyl-oligopeptidase, protease, and bromelain.
•  High concentration and enzymatic activity^**.
•  With calcium carbonate - calcium is a mineral that helps digestive enzymes work properly.
•  Formula with Tolerase^® G as the main raw material - DSM innovation (Netherlands).

Gzymes (Enzyme blend) will become your best ally

Gzymes (Enzyme blend) from EssentialSeries is a dietary supplement in veggie capsules, made with a specific blend of food-targeted enzymes and calcium.

The unique enzyme combo in HSN’s Gzymes (Enzyme blend) includes calcium carbonate, chosen for its role in supporting normal digestive enzyme function; and prolyl-oligopeptidase, papain, bromelain, and protease.

Try this combo of 4 high-concentration enzymes!

Gzymes (Enzyme blend) formula - here’s the full scoop!

How did the idea come about?

At HSN we research and have specialized teams studying market needs. Our products serve a clear purpose directly aimed at improving quality of life, so you won’t find formulas without a clear goal or based on flashy commercial trends without depth; our formulations are tailored to real population needs.

Discover Gzymes (Enzyme blend)!

Choosing the enzymes to use

The enzymes in Gzymes (Enzyme blend) were selected for the synergy they create together.

Gzymes (Enzyme blend) contains:

•  Papain.
•  Prolyl-oligopeptidase.
•  Protease.
•  Bromelain.

All present in optimal concentrations, combined with their enzymatic activity^**, make Gzymes (Enzyme blend) a complete, high-quality dietary supplement you don’t want to miss.

Why is calcium included?

You might wonder why calcium is added to a product combining food enzymes, right?

Tolerase® G, discover a groundbreaking patent

Tolerase^® G is the registered trademark DSM uses for its patented process developing the endopeptidase enzyme: prolyl-oligopeptidase.

This patent is internationally recognized, not only for the reputation and positive evaluation of the company behind it, but also for the supporting studies (see Bibliographic References), thanks to its unique and specific structure.

Some highlights of DSM’s patented enzyme are:

•  Prolyl-oligopeptidase is an enzymatic preparation with activity over 580 000 PPI/g (1).
•  Thanks to its chemical makeup, 'Prolyl-oligopeptidase' is a peptidase enzyme that hydrolyzes proline bonds (prolyl). Gluten is a prolamin, a protein naturally rich in proline (2).
• Tolerase^® G is stable and active in the acidic environment of the stomach.
•  It is resistant to digestion by pepsin.
•  Not synthetic - It’s an enzyme developed from food-grade Aspergillus niger.

High concentration and activity enzymes^** - How to recognize them

Enzymes have different values to consider compared to other compounds traditionally measured only by mass. For example, a compound like creatine is important to know by the amount used; with that info, you understand its effects. But enzymes work differently:

Our Gzymes (Enzyme blend) has the following nutritional composition:

The abbreviations for concentration refer to the activity units^** measured on the substrate:

•  USP: Units according to the United States Pharmacopeia.
•  PPI: One PPI is the amount of enzyme needed to release one picomol of pNA from Z-Gly-Pro-pNA in 1 s under assay conditions.
•  HUT: Hemoglobin units based on tyrosine (a proteolytic measure).
•  GDU: Gelatin digestion units (another proteolytic measure).

More products in this category you might like

At HSN we have many products aimed at various gut-related functions.

You can find our probiotics, more enzyme products like lactase, fibers like psyllium or glucomannan, and more.

Bibliographic references

•  (1) Specifications of the prolyl-oligopeptidase enzymatic preparation, Annex I, COMMISSION IMPLEMENTING DECISION (EU) 2017/1387 of 24 July 2017 authorizing the marketing of a prolyl-oligopeptidase enzymatic preparation produced with a genetically modified strain of Aspergillus niger as a novel food ingredient under Regulation (EC) No 258/97.
•  (2) Safety of proline-specific oligopeptidase as a novel food pursuant to Regulation (EC) No 258/97 Safety of proline‐specific oligopeptidase as a novel food pursuant to Regulation (EC) No 258/97 (wiley.com).
•   SCIENTIFIC OPINION: Scientific Opinion on the substantiation of health claims related to calcium and maintenance of bones and teeth (ID 224, 230, 231, 354, 3099), muscle function and neurotransmission (ID 226, 227, 230, 235), blood coagulation (ID 230, 236), energy-yielding metabolism (ID 234), function of digestive enzymes (ID 355), and maintenance of normal blood pressure (ID 225, 385, 1419) pursuant to Article 13(1) of Regulation (EC) No 1924/2006 https://efsa.onlinelibrary.wiley.com/doi/epdf/10.2903/j.efsa.2009.1210
•  Salden, B. N., Monserrat, V., Troost, F. J., Bruins, M. J., Edens, L., Bartholomé, R., … Masclee, A. A. (2015). Randomised clinical study: Aspergillus niger-derived enzyme digests gluten in the stomach of healthy volunteers. Alimentary Pharmacology and Therapeutics, 42(3), 273–285.
•  Tanner, G. J. (2021). Relative Rates of Gluten Digestion by Nine Commercial Dietary Digestive Supplements. Frontiers in Nutrition, 8, 784850.
•  Dunaevsky, Y. E., Tereshchenkova, V. F., Belozersky, M. A., Filippova, I. Y., Oppert, B., & Elpidina, E. N. (2021). Review effective degradation of gluten and its fragments by gluten-specific peptidases: A review on application for the treatment of patients with gluten sensitivity. Pharmaceutics, 13(10).
•  Stepniak, D., Spaenij-Dekking, L., Mitea, C., Moester, M., De Ru, A., Baak-Pablo, R., … Koning, F. (2006). Highly efficient gluten degradation with a newly identified prolyl endoprotease: Implications for celiac disease. American Journal of Physiology - Gastrointestinal and Liver Physiology, 291(4), G621-9.
•  Yoosuf, S., & Makharia, G. K. (2019). Evolving therapy for celiac disease. Frontiers in Pediatrics, 7(MAY), 193.
•  Mitea, C., Havenaar, R., Wouter Drijfhout, J., Edens, L., Dekking, L., Koning, F., & Dekking, E. H. A. (2008). Efficient degradation of gluten by a prolyl endoprotease in a gastrointestinal model: Implications for coeliac disease. Gut, 57(1), 25–32.
•  The Efficacy of Plant Enzymes Bromelain and Papain as a Tool for Reducing Gluten Immunogenicity from Wheat Bran.
•  Combination of Gluten-Digesting Enzymes Improved Symptoms of Non-Celiac Gluten Sensitivity: A Randomized Single-blind, Placebo-controlled Crossover Study.

^** Prolyl-oligopeptidase 580 000 PPI/g | Bromelain 2500 GDU/g | Protease 450 000 HUT/g | Papain 6000 USP/mg.