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Calcium D-glucarate is a food supplement derived from D-glucaric acid, a natural substance found in small amounts in fruits and vegetables such as oranges, apples, grapes, broccoli, and Brussels sprouts.
This compound has been studied for its potential benefits in detoxification and in reducing the risk of certain types of cancer.
This acid is metabolised in the human body and is believed to have properties that aid in the elimination of toxins through a process called glucuronidation. This process is crucial for the body’s detoxification, as it helps remove potentially harmful compounds through urine.
In recent decades, calcium D-glucarate has gained attention in alternative and complementary medicine for its potential protective effects against cancer. Preclinical studies have suggested that it may help reduce cancer risk by inhibiting an enzyme called beta-glucuronidase, which can break down glucuronide complexes and release potentially carcinogenic substances back into the body.
Among its potential benefits, we can highlight:
- Detoxification: Helps eliminate toxins from the body by supporting glucuronidation.
- Cancer protection: May reduce the risk of certain types of cancer by inhibiting beta-glucuronidase activity.
- Liver health: Contributes to liver health by supporting detoxification processes.
- Hormonal regulation: Helps maintain a healthy balance of oestrogen levels.
Index
What Functions Does Calcium D-Glucarate Serve in Your Body?
Calcium D-glucarate performs several important functions in the body, mainly related to detoxification and cellular health. Here is an overview of its main functions:
Regulation of Cholesterol Levels
Calcium D-glucarate may help reduce enterohepatic recirculation of cholesterol, which can lead to a decrease in overall cholesterol levels in the body. By inhibiting the enzyme beta-glucuronidase, calcium D-glucarate can help prevent the reabsorption of bile acids in the intestines. Bile acids are produced from cholesterol and excreted into the intestines. If not reabsorbed, the body uses more cholesterol to produce additional bile acids, which can reduce LDL (“bad”) cholesterol levels in the blood.
Body Detoxification
Calcium D-glucarate promotes glucuronidation, a vital process in which toxins and other harmful substances are conjugated with glucuronic acid and excreted from the body through urine. This helps to remove carcinogens, excess hormones, and other potentially harmful compounds. Calcium D-glucarate may enhance the elimination of bile acids and other lipophilic substances, helping to reduce LDL cholesterol and improve the overall lipid profile.
Liver Health
By facilitating the elimination of waste products and toxins, calcium D-glucarate supports healthy liver function, helping the liver maintain its detoxification and chemical processing capacity. A healthy liver is crucial for cholesterol regulation, as it produces and regulates cholesterol levels in the body. By supporting detoxification and liver function, calcium D-glucarate can indirectly help maintain healthy cholesterol levels.
Hormonal Balance
Calcium D-glucarate promotes oestrogen balance. This effect is due to its ability to influence the metabolism and elimination of oestrogens and other hormonal compounds. Calcium D-glucarate supports the glucuronidation process in the liver, where oestrogens are combined with glucuronic acid to form water-soluble compounds that can be excreted by the body. These glucuronidated oestrogen compounds are then excreted through urine and faeces, helping to maintain balanced hormone levels. Additionally, it inhibits beta-glucuronidase activity, reducing the likelihood of conjugated oestrogens being reabsorbed and recirculating in the body.
Prevention of Certain Types of Cancer
By inhibiting beta-glucuronidase. This enzyme, if active at elevated levels, can release conjugated toxins and carcinogens, allowing them to be reabsorbed into the body. Calcium D-glucarate inhibits this enzyme, reducing the risk of these compounds recirculating and causing cellular damage.
By facilitating the elimination of excess oestrogens, calcium D-glucarate may be beneficial for conditions associated with high oestrogen levels, such as premenstrual syndrome (PMS), endometriosis, and certain hormone-dependent cancers (e.g. breast and prostate cancer).
Reduction of Oxidative Stress
It may contribute to the reduction of cellular damage caused by free radicals, thereby supporting cellular health and reducing the risk of chronic diseases.
How to Take Calcium D-Glucarate?
Calcium D-glucarate is generally consumed as a food supplement. Here are some guidelines on how to take it:
- Capsules or tablets: This is the most common form.
- Powder: Sometimes available to mix with water or juice.
- Combinations: It can be found in combination with other detox products.
The recommended daily dose varies, but is commonly between 500 to 1500mg per day, divided into several doses.
For specific uses, depending on the goal (e.g., liver support), the dose may be adjusted according to the recommendation of a healthcare professional.
It can be taken with or without food, although some people prefer to take it with meals to avoid potential stomach discomfort. For maximum benefit, it is recommended to take it consistently.
Calcium D-Glucarate by EssentialSeries
Contraindications of Calcium D-Glucarate
Calcium D-glucarate, while generally considered safe for most people, may have some contraindications and possible side effects. It is important to consult with a healthcare professional before starting any new supplement. Here are some considerations and possible contraindications:
- Pregnancy and breastfeeding: There is not enough information on the safety of calcium D-glucarate during pregnancy and breastfeeding, so caution is advised.
- Drug interactions: It may interact with certain medications, especially those metabolised by the liver. This includes cholesterol medications, anticoagulants, and contraceptives. It may alter the efficacy of these medications by accelerating their elimination from the body.
- Liver conditions: Although it may benefit liver function, in individuals with pre-existing liver conditions, it is important to use it under medical supervision, as it could influence the metabolism of other drugs or toxins.
- Gastrointestinal side effects: Some people may experience mild side effects such as stomach discomfort, diarrhoea or gas.
- Allergic reactions: Although rare, some people may be allergic to this supplement. Any signs of an allergic reaction, such as skin rash, itching, swelling, or difficulty breathing, require immediate medical attention.
It is always crucial to speak with a doctor before taking calcium D-glucarate, especially if there are pre-existing medical conditions or if other medications are being taken.
Conclusions
Calcium D-glucarate is a valuable component of a healthy diet due to its multiple health benefits. By facilitating the detoxification of the body and promoting hormonal balance, this supplement supports vital functions that are essential for overall wellbeing. Its ability to enhance liver health and regulate cholesterol levels highlights its therapeutic potential, especially in preventing and managing chronic diseases such as cancer and cardiovascular diseases.
Recommended Bibliography
- Dwivedi, C., Heck, W. J., Downie, A. A., Larroya, S., & Webb, T. E. (1990). Effect of calcium glucarate on β-glucuronidase activity and glucarate content of certain vegetables and fruits. Biochemical Medicine and Metabolic Biology, 43(2), 83–92.
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