GI Biotics (Bacterial strains) 25B CFU - The most classic formula
GI Biotics (Bacterial strains) 25B CFU from EssentialSeries is our most 'one for all' bacterial strains formula, usually the best choice for anyone unsure which of our 'Biotics' options to pick. GI Biotics is formulated with a blend of bacterial strains cultures with 11 different strains, guaranteeing a total biological activity of 25 billion colony-forming units, combined with Inulin, FOS, Zinc, and Vitamin B2 (riboflavin).
GI Biotics is HSN’s most digestive formula, designed to act specifically on the gastrointestinal system thanks to the zinc in its composition, which helps normal macronutrient metabolism. It has been developed with a specific combination of bacterial strains from the families: Streptococcus, Lactobacillus, and Bifidobacterium. Plus, the presence of prebiotic fibers like fructooligosaccharides (FOS) and fructans (inulin).
The 25B CFU is not a quantity value but an activity measure, the correct way to gauge the effectiveness of a bacterial strains formula. Our 25B CFU is guaranteed until the product’s expiration date, unlike bacterial strains from other brands.
Discover GI Biotics - what makes it unique?
CFU. Know why it matters
Bacterial strains are microbes, and they must be alive.
The term 'bacterial strain,' as defined by the Spanish Agency for Food Safety and Nutrition:
Refers to bacterial species, bacterial strains, or species of living microorganisms, like Lactobacillus helveticus, Lactobacillus rhamnosus, etc.
And to meet this properly, the bacterial strains selected in the bacterial strains formula must be alive, so their biological activity (Colony Forming Units) must be known. However, many companies sell bacterial strains products where they only declare the milligrams of powder containing the bacteria. While practical for development, this is unspecific and not very informative for users regarding the formula’s effectiveness, what if the bacteria died in the powder? What good is the amount if there are no 'live bacterial strains'?
To avoid these issues, at HSN we indicate the correct value, the one that should be shown on any bacterial strain product to truly know its effectiveness and concentration: The Colony Forming Units 'CFU'. Any bacterial strain you buy, whether a single strain or a mix of several species, should tell you the units of bacteria it contains so you can precisely choose the best product for your needs.
25B CFU is an appropriate concentration for chronic, long-term use of a bacterial strain formula aimed at maintenance and without special requirements, a topic we’ll cover later in this description.
Specific selection of bacterial strains
Not all bacterial strains are the same, and we’re not just talking about bacterial strains as products, but about bacterial strains.
'Bacterial strain' is a broad term, there are hundreds of bacteria generally recognized as safe for human consumption and thus usable in food and supplements, but how do we know which strains are useful or beneficial?
We know through scientific studies conducted by researchers from multiple universities worldwide with many people over weeks or even months; these studies establish which specific bacteria have certain properties, which others do, and which have no beneficial physiological effects for the human body.
HSN’s GI Biotics formula was developed after reviewing the most current and significant scientific evidence on bacterial strains for use as a dietary supplement, and we chose a selection of 11 bacterial strains from the most recognized bacterial strain families in nutrition: Lactobacillus, Bifidobacterium, and Streptococcus.
You’ll find well-known strains like L. Acidophilus, L. Casei, L. Reuteri, and B. Bifidum, among others.
Controlled culture bacterial strains
Bacterial strains are bacteria that grow in specific environments, and bacterial strains bacteria intended to colonize the host and exert nutritional properties should not be confused with bacteria that naturally develop from food decomposition; although both are bacteria, some are beneficial and others harmful to humans, and they are completely different.
The bacteria used as bacterial strains in our Biotics range are bacterial strains grown in controlled media by biochemistry specialists, allowing them to multiply properly to reach billions of units in controlled environments and maximize all their beneficial effects.
Many companies buy bacterial strains cultivated by specialists in favorable media, which is easier because if all external conditions needed for bacterial strain growth are provided, it will multiply quickly and easily, but its resistance to the environment is lower. These bacterial strains require refrigeration, are very delicate, and die quickly and easily; in short, they are effective bacterial strain presentations only while alive but have very limited viability.
At HSN, we selected the growth conditions for our bacterial strains and established a culture medium considered 'non-optimal' for their growth. This doesn’t negatively affect their effectiveness; on the contrary, it’s more costly for the manufacturer because bacteria grow less well, but they are much more resistant to the environment because they have already survived a tough culture medium. This way, our bacteria don’t need special care, refrigeration, or specific environmental control, and their biological activity stays intact throughout the product’s use.
Bacterial strain / Symbiotic - The role of prebiotics
Bacterial strains are clearly defined as live bacterial strains ingested to colonize the host and perform nutritional functions, but when the term 'bacterial strains' was conceptualized, a parallel concept called 'prebiotic' emerged, categorizing a type of fiber with particular nutritional properties recommended in combination with bacterial strains.
The combination of bacterial strains + prebiotic is called symbiotic and is considered a superior formulation compared to either compound alone.
In HSN’s biotics formulas, we add prebiotics to our specific bacterial strains selections; you’ll find a mix of inulin and fructooligosaccharides in GI Biotics from HSN.
HSN Biotics don’t require refrigeration
One of the most delicate issues with bacterial strains that makes many market options ineffective due to lack of biological activity is the cold chain.
Bacterial strains cultivated in favorable conditions grow in controlled, refrigerated temperatures and require maintaining these conditions for survival, which creates clear logistical challenges at several points:
- Manufacturing: Even if bacterial strain developers have the industrial conditions for cold processing, supplement factories (final product) often don’t, so if the bacterial strain powder is handled without refrigeration during manufacturing, it’s no good.
- Shipping: Although there are more tools for refrigerated shipping, it remains a difficult process that raises costs for customers.
- Storage at home: Keeping bacterial strains in the fridge, taking up space, is objectively worse than storing them at room temperature.
However, with HSN you can avoid this: our bacterial strains survive room temperatures because they were cultivated at these temperatures, not in the cold, making their natural environment the ambient temperature. This means: more resistant bacterial strains, no need to maintain the cold chain throughout production and storage, both on our end and yours at home, and no extra cost on your purchase for these conditions.
A maintenance formula - how to combine it with 100B CFU?
Besides GI Biotics 25B, we have a 4x more concentrated version: 100B CFU, does this mean 100B CFU is better than 25B CFU?
No, each concentration suits different purposes, each having its place in the diet of someone using bacterial strains, depending on the moment.
25B CFU is considered the usual bacterial strain amount you should use daily for long-term nutritional benefits without special considerations, while 100B CFU is a bacterial strain for occasional use, in specific moments when you need that extra concentration, or for people with particular needs requiring that high concentration chronically.
A common way to use bacterial strains at one of the most usual times for taking them, which is: after antibiotic treatment, is to use GI Biotics 100B CFU for 60 days (2 months, the duration of one container) and once finished, continue bacterial strain intake with the 25B CFU version for 120 more days (4 months, the duration of one container). For a total use time of 6 months.
After this period, you can repeat the cycle, continue with the 25B maintenance dose, or stop use, depending on your needs.
Can bacterial strains be taken with other products?
Yes.
Bacterial strains are compatible with every compound commonly used as dietary supplementation; they can be taken together (even in the same dose) with:
And of course with proteins, carbohydrates, isotonics, mass gainers, and any other powder, capsule, or tablet product you can buy at HSN, so you can use GI Biotics completely worry-free alongside these products.
Scientific references on bacterial strains
- Sanders, M. E., Guarner, F., Guerrant, R., Holt, P. R., Quigley, E. M. M., Sartor, R. B., … Mayer, E. A. (2013). An update on the use and investigation of probiotics in health and disease. Gut, 62(5), 787–796.
- Shing, C. M., Peake, J. M., Lim, C. L., Briskey, D., Walsh, N. P., Fortes, M. B., … Vitetta, L. (2014). Effects of probiotics supplementation on gastrointestinal permeability, inflammation and exercise performance in the heat. European Journal of Applied Physiology, 114(1), 93–103.
- Hempel, S., Newberry, S. J., Maher, A. R., Wang, Z., Miles, J. N. V., Shanman, R., … Shekelle, P. G. (2012). Probiotics for the prevention and treatment of antibiotic-associated diarrhea: A systematic review and meta-analysis. JAMA - Journal of the American Medical Association, 307(18), 1959–1969.
- McFarland, L. V. (2007). Meta-analysis of probiotics for the prevention of traveler’s diarrhea. Travel Medicine and Infectious Disease, 5(2 SPEC. ISS.), 97–105.
- Jäger, R., Mohr, A. E., Carpenter, K. C., Kerksick, C. M., Purpura, M., Moussa, A., … Antonio, J. (2019). International Society of Sports Nutrition Position Stand: Probiotics. Journal of the International Society of Sports Nutrition, 16(1), 62.
- Wilkins, T., & Sequoia, J. (2017). Probiotics for Gastrointestinal Conditions: A Summary of the Evidence. American Family Physician, 96(3), 170–178.