What are the health benefits of Norvaline?

Carlos Sánchez 4 min. of reading Sport Performance Leave a comment

Norvaline is a supplement that is gaining popularity in the world of sport due to its ability to increase nitric oxide (NO) levels in the body indirectly.

Norvaline works by blocking the arginase enzyme, allowing arginine to be used more effectively to produce nitric oxide. This improves circulation, the transport of oxygen and nutrients, and helps remove waste products from the muscle.

In this article, we explain how norvaline can help you perform better in intense and strength-based activities, especially when you combine it with other supplements such as creatine. Discover everything this amino acid can do for you!

1 Supports cardiovascular health

At vascular level, low NO production combined with overstimulation of arginase leads to poorer relaxation of the blood vessels, greater vessel stiffness, and adaptations that reduce the diameter available for blood flow, such as hyperplasia of the muscle cells that make up the vessel.

All of this has a negative effect, promoting the development of cardiovascular diseases.

In addition to its benefits for sports performance, blocking the arginase enzyme could have interesting medical applications.

Experimental studies have shown that blocking arginase could help treat hypertension. On the other hand, greater arginine availability, promoted through supplementation with arginine itself or with citrulline, reduces the effects of sickle cell disease or sickle cell anaemia, a condition in which red blood cells die prematurely.

2 Helps control the effects of diabetes

Diabetes is another condition in which there appears to be an overstimulation of the arginase enzyme, resulting in poorer contractility of the blood vessel walls and, ultimately, poorer vascular function. Likewise, in cases of obesity, dysfunction of the circulatory system also occurs, partly driven by a pro-inflammatory and pro-oxidative state.

These processes increase arginase activity, and treatment with inhibitors of this enzyme in animal models has been shown to prevent these complications.

3 Helps with cardiovascular complications

Arginase is also overstimulated in cases of atherosclerosis, a cardiovascular complication characterised by the formation of plaques that obstruct blood flow.

Important: If you have cardiovascular problems, consult your doctor before taking norvaline or any other supplement (such as citrulline, arginine or nitrates), as they could interfere with your medication.

4 Improves renal processes

At renal level, excessive arginase activity may also contribute to the development of kidney disorders, but it has not been possible to demonstrate that supplementation with arginine or citrulline can improve NO availability and reduce markers of kidney damage.

5 May be used in the treatment of neurodegenerative diseases

Some studies have shown that, in diseases such as multiple sclerosis or Alzheimer’s disease, inhibition could be beneficial, as it has been observed that arginase appears to be overstimulated in both conditions.

Discover HSN L-Norvaline

At HSN, we understand that improving in sport requires effective strategies and quality supplements. That is why we offer you a food supplement in vegetable capsules made with pure L-norvaline amino acid, chelated iron bisglycinate and vitamin B1 from thiamine hydrochloride.

Buy supplements with Norvaline at HSN

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/norvaline#section=Top
https://www.dietspotlight.com/l-norvaline/
Caldwell et al., (2018). Arginase: a multifacet enzyme important in health and disease.
El-Bassossy et al., (2012). Arginase inhibition alleviates hypertension associated diabetes: effect on endothelial dependent relaxation and NO production.
Durante et al., (2007). Arginase: a critical regulator of nitric oxide synthesis and vascular function.
Hunter & Downs (1944). The inhibition of arginase by amino acids.

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