Did you know that Creatine decreases the Myostatin levels?

Did you know that Creatine decreases the Myostatin levels?

Have you ever thought what is the connection between creatine and myostatin? If you are not sure, reading this post will definitely help you understand how taking creatine affects myostatin. In other words, we will talk about its effects on the sport performance. Learn all the keys!


What does creatine do in our body?

Creatine is one of the most popular supplements nowadays, specially among those who want to gain muscle mass and improve the performance. You probably knew that already. But, do you know how it works in your body? Let’s make a brief summary.

Creatine is a compound obtained from the amino acids glycine, arginine, and methionine. The pancreas and liver are the ones in charge of synthesizing this compound, which is fundamental for the energy reserves in the muscles.

Your body produces around 2 grams of creatine naturally every day. It is also available in some food like meat and fish (read more). In addition, you can take an extra supply from supplementation. Our body stores around a 95% of this substance in the skeletal muscle, while a small part goes to the brain and testicles.

It is transported to target cells with high requirements like the ones from the skeletal muscle. This task is performed by a specific creatine transporter (a transmembrane protein that filters creatine from the blood to the muscle cells).

Couple doing push ups

What is the role of this ergogenic help in the energy system?

If you usually take creatine, you probably know that this supplement provides energy to the cells. In fact, it immediately recharges and maintains the ATP (Adenosine Triphosphate) levels.

Particularly, creatine helps us transform ADP (adenosine diphosphate) and AMP (adenosine monophosphate) into ATP. Consequently, this prevents the production of lactic acid in the muscles.

Thus, the supraphysiological creatine levels (phosphocreatine and free creatine) will allow us to remain for a longer period of time under tension during a strength exercise.

When ATP is broken down it releases a phosphate molecule that creatine “absorbs” to form and store phosphocreatine. Then, phosphocreatine gives up its phosphate molecule to ADP to produce ATP once again thanks to creatine kinase.

But how does this energy transport system from creatine affect our body? Quite simple: it will be an excellent ally when we do highly stressful activities

But the aim of this article is not to focus on the ergogenic properties of creatine to improve the physical composition (gain muscle mass, cell volume), gain strength or improve the sport performance at a high intensity. What is truly interesting, since we are used to its usual benefits, is its anti-catabolic potential.

It seems that, according to several studies, creatine supplements could work as a myostatin “blocker” during the workout.

What is myostatin?

Myostatin is a powerful muscle mass catabolic regulator. In fact, it is a growth inhibitor of the skeletal muscle. What does this mean? To put it briefly, it “stops” the protein synthesis when it binds to muscle cell receptors, causing atrophy


Its deficiency, caused by a genetic mutation, leads to muscle hypertrophy. On the contrary, an increase will cause muscle atrophy. It seems that it directly affects satellite cells.

Then, how does creatine affect the myostatin levels?

The university of Arak, Iran, conducted a study for 8 weeks that concluded: RT+CR lead to greater decreases in serum myostatin.


An endurance training routine will also decrease the myostatin levels, inhibiting this agent.

Moreover, the group that performed an endurance workout and took 1 daily dose of creatine (0.05 g/kg after 1 week of loading phase) had better results when it came to decreasing the myostatin levels.

These possible benefits (together with the fact that they do not trigger side effects) suggest that we could take higher doses of creatine throughout the day. Obviously, as long as we are following safe methodologies and protocols that best suit your needs. Even though some may be more similar and other very different, let’s keep on going!

Did we miss something? If you have any question, you can leave a comment or get in touch with us via Twitter: @Science4Fitness. We are here to help you!


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About Science4Fitness
Science4Fitness is a team made up by Cristian Álvarez and Julián Bahamontes, both are passionate about nutrition and sport, the former is specialized in nutrition and the latter in training.
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